Endocrine Abstracts

Benign prostatic hyperplasia and prostate cancer are androgen-dependent diseases. Dihydrotestosterone (DHT) is a 5α-reduced metabolite of testosterone (T), which is the causative factor for the progression of these diseases. The 5α-reductase enzyme (5α-R) converts T to DHT, which is responsible for increasing cell proliferation, and hence inhibition of this enzyme could lead to potential treatments for these afflictions. This study aimed to determine the biologi...